What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?
Identifieur interne : 000200 ( Istex/Checkpoint ); précédent : 000199; suivant : 000201What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?
Auteurs : J-P Pelletier [Canada] ; C. Cooper [Royaume-Uni] ; C. Peterfy [États-Unis] ; J-Y Reginster [Belgique] ; M-L Brandi [Italie] ; O. Bruyère [Belgique] ; R. Chapurlat [France] ; F. Cicuttini [Australie] ; P G Conaghan [Royaume-Uni] ; M. Doherty [Royaume-Uni] ; H. Genant [États-Unis] ; G. Giacovelli [Italie] ; M C Hochberg [États-Unis] ; D J Hunter [Australie] ; J A Kanis [Royaume-Uni] ; M. Kloppenburg [Pays-Bas] ; J-D Laredo [France] ; T. Mcalindon [États-Unis] ; M. Nevitt [États-Unis] ; J-P Raynauld [Canada] ; R. Rizzoli [Suisse] ; C. Zilkens [Allemagne] ; F W Roemer [Allemagne, États-Unis] ; J. Martel-Pelletier [Canada] ; A. Guermazi [États-Unis]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2013-10.
English descriptors
- KwdEn :
- Advisory boards, Amgen, Articular, Articular cartilage, Bone marrow lesions, Cartilage, Cartilage defects, Cartilage loss, Cartilage thickness, Cartilage volume, Cartilage volume loss, Clinical trials, Consulting fees, Dmoad, Dohme, Economic aspects, Effusion, Endpoint, Esceo, Extrusion, Grant support, Guermazi, Higher risk, Imaging, Joint effusion, Joint replacement, Joint structure, Knee osteoarthritis, Knee osteoarthritis patients, Knee pain, Knee replacement, Knee replacement surgery, Knee replacements, Kwoh, Lecture fees, Lesion, Longitudinal, Longitudinal study, Magnetic resonance imaging, Medial, Medial compartment, Meniscal, Meniscal damage, Meniscal lesions, Meniscal tears, Merck, Novartis, Oecd, Osteoarthritis, Osteoarthritis cartilage hunter, Osteoarthritis initiative, Osteoporosis, Patients risk, Pelletier, Predictive value, Predictor, Progression, Quantitative methods, Radiographic, Radiography, Radiology, Raynauld, Resonance imaging, Rheum, Rheumatology, Right knee, Risk factors, Roemer, Semiquantitative, Semiquantitative methods, Servier, Structural change, Structural changes, Subchondral, Synovial, Synovitis, Tibial, Tibial cartilage volume loss, Tibiofemoral, Total knee replacement, Virtual knee replacement, Wluka.
- Teeft :
- Advisory boards, Amgen, Articular, Articular cartilage, Bone marrow lesions, Cartilage, Cartilage defects, Cartilage loss, Cartilage thickness, Cartilage volume, Cartilage volume loss, Clinical trials, Consulting fees, Dmoad, Dohme, Economic aspects, Effusion, Endpoint, Esceo, Extrusion, Grant support, Guermazi, Higher risk, Imaging, Joint effusion, Joint replacement, Joint structure, Knee osteoarthritis, Knee osteoarthritis patients, Knee pain, Knee replacement, Knee replacement surgery, Knee replacements, Kwoh, Lecture fees, Lesion, Longitudinal, Longitudinal study, Magnetic resonance imaging, Medial, Medial compartment, Meniscal, Meniscal damage, Meniscal lesions, Meniscal tears, Merck, Novartis, Oecd, Osteoarthritis, Osteoarthritis cartilage hunter, Osteoarthritis initiative, Osteoporosis, Patients risk, Pelletier, Predictive value, Predictor, Progression, Quantitative methods, Radiographic, Radiography, Radiology, Raynauld, Resonance imaging, Rheum, Rheumatology, Right knee, Risk factors, Roemer, Semiquantitative, Semiquantitative methods, Servier, Structural change, Structural changes, Subchondral, Synovial, Synovitis, Tibial, Tibial cartilage volume loss, Tibiofemoral, Total knee replacement, Virtual knee replacement, Wluka.
Abstract
Knee osteoarthritis is associated with structural changes in the joint. Despite its many drawbacks, radiography is the current standard for evaluating joint structure in trials of potential disease-modifying osteoarthritis drugs. MRI is a non-invasive alternative that provides comprehensive imaging of the whole joint. Frequently used MRI measurements in knee osteoarthritis are cartilage volume and thickness; others include synovitis, synovial fluid effusions, bone marrow lesions (BML) and meniscal damage. Joint replacement is considered a clinically relevant outcome in knee osteoarthritis; however, its utility in clinical trials is limited. An alternative is virtual knee replacement on the basis of symptoms and structural damage. MRI may prove to be a good alternative to radiography in definitions of knee replacement. One of the MRI parameters that predicts knee replacement is medial compartment cartilage volume/thickness, which correlates with radiographic joint space width, is sensitive to change, and predicts outcomes in a continuous manner. Other MRI parameters include BML and meniscal lesions. MRI appears to be a viable alternative to radiography for the evaluation of structural changes in knee osteoarthritis and prediction of joint replacement.
Url:
DOI: 10.1136/annrheumdis-2013-203631
Affiliations:
- Allemagne, Australie, Belgique, Canada, France, Italie, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Bavière, Californie, District de Düsseldorf, District de Moyenne-Franconie, Hollande-Méridionale, Maryland, Massachusetts, Nottinghamshire, Nouvelle-Galles du Sud, Oxfordshire, Province de Liège, Rhénanie-du-Nord-Westphalie, Rhône-Alpes, Région wallonne, Victoria (État), Île-de-France
- Düsseldorf, Erlangen, Leyde, Liège, Lyon, Melbourne, Nottingham, Oxford, Paris, Sydney
- Université d'Oxford, Université de Liège, Université de Nottingham, Université de Sydney
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Cooper</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Peterfy, C" sort="Peterfy, C" uniqKey="Peterfy C" first="C" last="Peterfy">C. Peterfy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Spire Sciences, LLC, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Reginster, J Y" sort="Reginster, J Y" uniqKey="Reginster J" first="J-Y" last="Reginster">J-Y Reginster</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Brandi, M L" sort="Brandi, M L" uniqKey="Brandi M" first="M-L" last="Brandi">M-L Brandi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Metabolic Bone Unit, Department of Internal Medicine, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Bruyere, O" sort="Bruyere, O" uniqKey="Bruyere O" first="O" last="Bruyère">O. Bruyère</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Chapurlat, R" sort="Chapurlat, R" uniqKey="Chapurlat R" first="R" last="Chapurlat">R. Chapurlat</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Service de Rhumatologie et Pathologie Osseuse, INSERM UMR 1033 and Université de Lyon, Hôpital Edouard Herriot, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Cicuttini, F" sort="Cicuttini, F" uniqKey="Cicuttini F" first="F" last="Cicuttini">F. Cicuttini</name><affiliation wicri:level="3"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Public Health and Preventive Medicine, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Conaghan, P G" sort="Conaghan, P G" uniqKey="Conaghan P" first="P G" last="Conaghan">P G Conaghan</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Doherty, M" sort="Doherty, M" uniqKey="Doherty M" first="M" last="Doherty">M. Doherty</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Genant, H" sort="Genant, H" uniqKey="Genant H" first="H" last="Genant">H. Genant</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Radiology, Medicine, Epidemiology and Orthopedic Surgery, University of California, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Giacovelli, G" sort="Giacovelli, G" uniqKey="Giacovelli G" first="G" last="Giacovelli">G. Giacovelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Research Unit, Rottapharm|Madaus Group, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Hochberg, M C" sort="Hochberg, M C" uniqKey="Hochberg M" first="M C" last="Hochberg">M C Hochberg</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hunter, D J" sort="Hunter, D J" uniqKey="Hunter D" first="D J" last="Hunter">D J Hunter</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Kanis, J A" sort="Kanis, J A" uniqKey="Kanis J" first="J A" last="Kanis">J A Kanis</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Kloppenburg, M" sort="Kloppenburg, M" uniqKey="Kloppenburg M" first="M" last="Kloppenburg">M. Kloppenburg</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Rheumatology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Laredo, J D" sort="Laredo, J D" uniqKey="Laredo J" first="J-D" last="Laredo">J-D Laredo</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Radiology, Bone and Joint Imaging Unit, Lariboisière Hospital, Assistance publique des hôpitaux de Paris and Université Paris-Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mcalindon, T" sort="Mcalindon, T" uniqKey="Mcalindon T" first="T" last="Mcalindon">T. Mcalindon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, Tufts Medical Center, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Nevitt, M" sort="Nevitt, M" uniqKey="Nevitt M" first="M" last="Nevitt">M. Nevitt</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, OAI Coordinating Center, University of California, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Raynauld, J P" sort="Raynauld, J P" uniqKey="Raynauld J" first="J-P" last="Raynauld">J-P Raynauld</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Rizzoli, R" sort="Rizzoli, R" uniqKey="Rizzoli R" first="R" last="Rizzoli">R. Rizzoli</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Division of Bone Diseases, Geneva University Hospital and Faculty of Medicine, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Zilkens, C" sort="Zilkens, C" uniqKey="Zilkens C" first="C" last="Zilkens">C. Zilkens</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Faculty, Department of Orthopaedic Surgery, University of Dusseldorf, Dusseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Roemer, F W" sort="Roemer, F W" uniqKey="Roemer F" first="F W" last="Roemer">F W Roemer</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiology, University of Erlangen, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Martel Pelletier, J" sort="Martel Pelletier, J" uniqKey="Martel Pelletier J" first="J" last="Martel-Pelletier">J. Martel-Pelletier</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Guermazi, A" sort="Guermazi, A" uniqKey="Guermazi A" first="A" last="Guermazi">A. Guermazi</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the Rheumatic Diseases</title><title level="j" type="abbrev">Ann Rheum Dis</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><date type="published" when="2013-10">2013-10</date><biblScope unit="volume">72</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1594">1594</biblScope></imprint><idno type="ISSN">0003-4967</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-4967</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Advisory boards</term><term>Amgen</term><term>Articular</term><term>Articular cartilage</term><term>Bone marrow lesions</term><term>Cartilage</term><term>Cartilage defects</term><term>Cartilage loss</term><term>Cartilage thickness</term><term>Cartilage volume</term><term>Cartilage volume loss</term><term>Clinical trials</term><term>Consulting fees</term><term>Dmoad</term><term>Dohme</term><term>Economic aspects</term><term>Effusion</term><term>Endpoint</term><term>Esceo</term><term>Extrusion</term><term>Grant support</term><term>Guermazi</term><term>Higher risk</term><term>Imaging</term><term>Joint effusion</term><term>Joint replacement</term><term>Joint structure</term><term>Knee osteoarthritis</term><term>Knee osteoarthritis patients</term><term>Knee pain</term><term>Knee replacement</term><term>Knee replacement surgery</term><term>Knee replacements</term><term>Kwoh</term><term>Lecture fees</term><term>Lesion</term><term>Longitudinal</term><term>Longitudinal study</term><term>Magnetic resonance imaging</term><term>Medial</term><term>Medial compartment</term><term>Meniscal</term><term>Meniscal damage</term><term>Meniscal lesions</term><term>Meniscal tears</term><term>Merck</term><term>Novartis</term><term>Oecd</term><term>Osteoarthritis</term><term>Osteoarthritis cartilage hunter</term><term>Osteoarthritis initiative</term><term>Osteoporosis</term><term>Patients risk</term><term>Pelletier</term><term>Predictive value</term><term>Predictor</term><term>Progression</term><term>Quantitative methods</term><term>Radiographic</term><term>Radiography</term><term>Radiology</term><term>Raynauld</term><term>Resonance imaging</term><term>Rheum</term><term>Rheumatology</term><term>Right knee</term><term>Risk factors</term><term>Roemer</term><term>Semiquantitative</term><term>Semiquantitative methods</term><term>Servier</term><term>Structural change</term><term>Structural changes</term><term>Subchondral</term><term>Synovial</term><term>Synovitis</term><term>Tibial</term><term>Tibial cartilage volume loss</term><term>Tibiofemoral</term><term>Total knee replacement</term><term>Virtual knee replacement</term><term>Wluka</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Advisory boards</term><term>Amgen</term><term>Articular</term><term>Articular cartilage</term><term>Bone marrow lesions</term><term>Cartilage</term><term>Cartilage defects</term><term>Cartilage loss</term><term>Cartilage thickness</term><term>Cartilage volume</term><term>Cartilage volume loss</term><term>Clinical trials</term><term>Consulting fees</term><term>Dmoad</term><term>Dohme</term><term>Economic aspects</term><term>Effusion</term><term>Endpoint</term><term>Esceo</term><term>Extrusion</term><term>Grant support</term><term>Guermazi</term><term>Higher risk</term><term>Imaging</term><term>Joint effusion</term><term>Joint replacement</term><term>Joint structure</term><term>Knee osteoarthritis</term><term>Knee osteoarthritis patients</term><term>Knee pain</term><term>Knee replacement</term><term>Knee replacement surgery</term><term>Knee replacements</term><term>Kwoh</term><term>Lecture fees</term><term>Lesion</term><term>Longitudinal</term><term>Longitudinal study</term><term>Magnetic resonance imaging</term><term>Medial</term><term>Medial compartment</term><term>Meniscal</term><term>Meniscal damage</term><term>Meniscal lesions</term><term>Meniscal tears</term><term>Merck</term><term>Novartis</term><term>Oecd</term><term>Osteoarthritis</term><term>Osteoarthritis cartilage hunter</term><term>Osteoarthritis initiative</term><term>Osteoporosis</term><term>Patients risk</term><term>Pelletier</term><term>Predictive value</term><term>Predictor</term><term>Progression</term><term>Quantitative methods</term><term>Radiographic</term><term>Radiography</term><term>Radiology</term><term>Raynauld</term><term>Resonance imaging</term><term>Rheum</term><term>Rheumatology</term><term>Right knee</term><term>Risk factors</term><term>Roemer</term><term>Semiquantitative</term><term>Semiquantitative methods</term><term>Servier</term><term>Structural change</term><term>Structural changes</term><term>Subchondral</term><term>Synovial</term><term>Synovitis</term><term>Tibial</term><term>Tibial cartilage volume loss</term><term>Tibiofemoral</term><term>Total knee replacement</term><term>Virtual knee replacement</term><term>Wluka</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Knee osteoarthritis is associated with structural changes in the joint. Despite its many drawbacks, radiography is the current standard for evaluating joint structure in trials of potential disease-modifying osteoarthritis drugs. MRI is a non-invasive alternative that provides comprehensive imaging of the whole joint. Frequently used MRI measurements in knee osteoarthritis are cartilage volume and thickness; others include synovitis, synovial fluid effusions, bone marrow lesions (BML) and meniscal damage. Joint replacement is considered a clinically relevant outcome in knee osteoarthritis; however, its utility in clinical trials is limited. An alternative is virtual knee replacement on the basis of symptoms and structural damage. MRI may prove to be a good alternative to radiography in definitions of knee replacement. One of the MRI parameters that predicts knee replacement is medial compartment cartilage volume/thickness, which correlates with radiographic joint space width, is sensitive to change, and predicts outcomes in a continuous manner. Other MRI parameters include BML and meniscal lesions. MRI appears to be a viable alternative to radiography for the evaluation of structural changes in knee osteoarthritis and prediction of joint replacement.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Bavière</li><li>Californie</li><li>District de Düsseldorf</li><li>District de Moyenne-Franconie</li><li>Hollande-Méridionale</li><li>Maryland</li><li>Massachusetts</li><li>Nottinghamshire</li><li>Nouvelle-Galles du Sud</li><li>Oxfordshire</li><li>Province de Liège</li><li>Rhénanie-du-Nord-Westphalie</li><li>Rhône-Alpes</li><li>Région wallonne</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Düsseldorf</li><li>Erlangen</li><li>Leyde</li><li>Liège</li><li>Lyon</li><li>Melbourne</li><li>Nottingham</li><li>Oxford</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Liège</li><li>Université de Nottingham</li><li>Université de Sydney</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Pelletier, J P" sort="Pelletier, J P" uniqKey="Pelletier J" first="J-P" last="Pelletier">J-P Pelletier</name></noRegion><name sortKey="Martel Pelletier, J" sort="Martel Pelletier, J" uniqKey="Martel Pelletier J" first="J" last="Martel-Pelletier">J. Martel-Pelletier</name><name sortKey="Raynauld, J P" sort="Raynauld, J P" uniqKey="Raynauld J" first="J-P" last="Raynauld">J-P Raynauld</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Cooper, C" sort="Cooper, C" uniqKey="Cooper C" first="C" last="Cooper">C. Cooper</name></noRegion><name sortKey="Conaghan, P G" sort="Conaghan, P G" uniqKey="Conaghan P" first="P G" last="Conaghan">P G Conaghan</name><name sortKey="Cooper, C" sort="Cooper, C" uniqKey="Cooper C" first="C" last="Cooper">C. Cooper</name><name sortKey="Doherty, M" sort="Doherty, M" uniqKey="Doherty M" first="M" last="Doherty">M. Doherty</name><name sortKey="Kanis, J A" sort="Kanis, J A" uniqKey="Kanis J" first="J A" last="Kanis">J A Kanis</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Peterfy, C" sort="Peterfy, C" uniqKey="Peterfy C" first="C" last="Peterfy">C. Peterfy</name></region><name sortKey="Genant, H" sort="Genant, H" uniqKey="Genant H" first="H" last="Genant">H. Genant</name><name sortKey="Guermazi, A" sort="Guermazi, A" uniqKey="Guermazi A" first="A" last="Guermazi">A. Guermazi</name><name sortKey="Hochberg, M C" sort="Hochberg, M C" uniqKey="Hochberg M" first="M C" last="Hochberg">M C Hochberg</name><name sortKey="Mcalindon, T" sort="Mcalindon, T" uniqKey="Mcalindon T" first="T" last="Mcalindon">T. Mcalindon</name><name sortKey="Nevitt, M" sort="Nevitt, M" uniqKey="Nevitt M" first="M" last="Nevitt">M. Nevitt</name><name sortKey="Roemer, F W" sort="Roemer, F W" uniqKey="Roemer F" first="F W" last="Roemer">F W Roemer</name></country><country name="Belgique"><region name="Région wallonne"><name sortKey="Reginster, J Y" sort="Reginster, J Y" uniqKey="Reginster J" first="J-Y" last="Reginster">J-Y Reginster</name></region><name sortKey="Bruyere, O" sort="Bruyere, O" uniqKey="Bruyere O" first="O" last="Bruyère">O. Bruyère</name></country><country name="Italie"><noRegion><name sortKey="Brandi, M L" sort="Brandi, M L" uniqKey="Brandi M" first="M-L" last="Brandi">M-L Brandi</name></noRegion><name sortKey="Giacovelli, G" sort="Giacovelli, G" uniqKey="Giacovelli G" first="G" last="Giacovelli">G. Giacovelli</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Chapurlat, R" sort="Chapurlat, R" uniqKey="Chapurlat R" first="R" last="Chapurlat">R. Chapurlat</name></region><name sortKey="Laredo, J D" sort="Laredo, J D" uniqKey="Laredo J" first="J-D" last="Laredo">J-D Laredo</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Cicuttini, F" sort="Cicuttini, F" uniqKey="Cicuttini F" first="F" last="Cicuttini">F. Cicuttini</name></region><name sortKey="Hunter, D J" sort="Hunter, D J" uniqKey="Hunter D" first="D J" last="Hunter">D J Hunter</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Kloppenburg, M" sort="Kloppenburg, M" uniqKey="Kloppenburg M" first="M" last="Kloppenburg">M. Kloppenburg</name></region></country><country name="Suisse"><noRegion><name sortKey="Rizzoli, R" sort="Rizzoli, R" uniqKey="Rizzoli R" first="R" last="Rizzoli">R. Rizzoli</name></noRegion></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Zilkens, C" sort="Zilkens, C" uniqKey="Zilkens C" first="C" last="Zilkens">C. Zilkens</name></region><name sortKey="Roemer, F W" sort="Roemer, F W" uniqKey="Roemer F" first="F W" last="Roemer">F W Roemer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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